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Rare thyroid cancer; GLP-1s carry an FDA black-box warning for personal or family history of MTC or MEN 2.
Medullary thyroid carcinoma (MTC) is a rare cancer of the parafollicular C cells of the thyroid. All GLP-1 receptor agonists carry an FDA black-box warning contraindicating use in patients with personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). The warning is based on rodent studies; human relevance is uncertain.