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Gradual dose increase over weeks to build tolerance and minimize GI side effects. Typical GLP-1 schedule: 4-week steps up to the maintenance dose.
Titration is the practice of starting a drug at a low dose and increasing in steps to reach the target maintenance dose. For GLP-1s, this is critical because GI side effects (nausea, vomiting, diarrhea) are dose-dependent. Wegovy: 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg over 16 weeks. Skipping titration triples discontinuation rates from intolerable nausea.