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Mixed evidence. Rapid weight loss generally reduces bone density. GLP-1 medications may have bone-protective effects partially offsetting this. Strength training is the proven mitigation.
Mixed evidence. Rapid weight loss generally reduces bone density. GLP-1 medications may have bone-protective effects partially offsetting this. Strength training is the proven mitigation.
Weight loss of any cause reduces bone mineral density 1-2% per 10% body weight lost. GLP-1 medications may have direct bone-protective effects (animal studies show GLP-1 receptors on osteoblasts/osteoclasts), but human data is limited. STEP-1 trial showed no clinically significant bone density change at 68 weeks. Risk factors: postmenopausal women, older men, prior fracture history, low BMI to start. Mitigation: resistance training 2-3x/week (non-negotiable), adequate calcium (1200mg/day) + vitamin D (2000 IU/day), DEXA scan baseline + annual if high-risk.