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Side effect profiles are similar. Zepbound users report slightly more fatigue at higher doses (10mg+). Wegovy users report more sulfur burps. Discontinuation rates ~comparable.
Side effect profiles are similar. Zepbound users report slightly more fatigue at higher doses (10mg+). Wegovy users report more sulfur burps. Discontinuation rates ~comparable.
Side effects of Wegovy (semaglutide) and Zepbound (tirzepatide) overlap heavily — nausea, constipation, diarrhea, fatigue, headache. SURMOUNT-1 vs SELECT discontinuation rates are within 1-2 percentage points. Patient reports on Reddit (r/Zepbound, r/WegovyWeightLoss) suggest qualitative differences: Wegovy users describe more "sulfur burps" (a semaglutide-specific finding) while Zepbound users report more fatigue at maintenance doses (10mg+). Tirzepatide users report less food noise but stronger weight-loss effect. If you have severe GI sensitivity, slower titration helps with either drug. If you have a history of pancreatitis, both drugs carry similar warnings.