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Yes — and you should. Exercise on Wegovy preserves lean muscle mass, prevents the ~30% lean mass loss seen in patients who lose weight without strength training.
Exercise on Wegovy is not just allowed — it is medically recommended. Without resistance training, ~30-40% of total weight loss on GLP-1 medications comes from lean muscle mass (vs fat). This becomes a long-term metabolic problem if you discontinue Wegovy. Recommendations: (1) Resistance training 2-3x/week is non-negotiable — protect muscle mass; (2) Cardiovascular exercise 150 minutes/week per CDC guidelines, but listen to your body — early-titration fatigue is normal; (3) Hydrate aggressively — GLP-1 dehydration risk is real, especially with high-intensity exercise; (4) Adequate protein intake (1.2-1.6g/kg body weight/day) supports muscle preservation. Many patients report exercise feels harder in first 4-8 weeks; this normalizes by maintenance dose.
Editorial answer reviewed by a board-certified clinician. Not medical advice. Coordinate treatment decisions with your prescriber.