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tirzepatide (Mounjaro) and diarrhea: incidence, timing, management, and when to escalate.
First weeks of each titration step.
GIP component may contribute to faster transit in some patients.
Low-fat meals, loperamide PRN.
Bloody stool, fever, severe dehydration.
Diarrhea on Mounjaro is the side effect most often reported above semaglutide. If it is persistent, the GIP component may not suit your gut profile.
Editorial summary, not medical advice. Incidence figures from FDA prescribing information and pivotal trial publications. Individual experience varies. Coordinate side effect management with your prescriber.