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What to expect on Ozempic (semaglutide) from your first injection through maintenance: appetite changes, side-effect onset, and weight-loss milestones.
First injection at 0.25 mg (sub-therapeutic for glucose control). Mild appetite changes for some users.
Titration to 0.5 mg. A1C-lowering effect begins. Some weight loss (2-4 lbs typical).
Most patients reach therapeutic 1 mg. A1C drop of 1-1.5 percentage points typical. Weight loss continues.
A1C continues to fall. SUSTAIN-6 cohort averaged ~1.5% A1C reduction at 6 months on 1 mg.
Maximum A1C effect (~1.5-2% reduction) and weight loss (5-15% body weight) sustained on maintenance dose.
Editorial summary based on pivotal trial titration schedules and real-world reports. Individual timelines vary. Not medical advice.